The study involved 20 healthy participants, each of whom had previously taken some form of psychedelic drug. Each participant received either 75 micrograms of LSD or a placebo, and their brains were then imaged.
The results revealed that the barriers between the sections of the brain that perform specialised functions break down under the influence of LSD. This means that, as mentioned, more of the brain is involved in visual processing, which causes the hallucinations, but it also contributes to the altered consciousness associated with LSD.
"It is also related to what people sometimes call 'ego-dissolution', which means the normal sense of self is broken down and replaced by a sense of reconnection with themselves, others and the natural world. This experience is sometimes framed in a religious or spiritual way -- and seems to be associated with improvements in well-being after the drug's effects have subsided," Carhart-Harris said.
"Our brains become more constrained and compartmentalised as we develop from infancy into adulthood, and we may become more focused and rigid in our thinking as we mature. In many ways, the brain in the LSD state resembles the state our brains were in when we were infants: free and unconstrained. This also makes sense when we consider the hyper-emotional and imaginative nature of an infant's mind."
Adding music to the mix caused even more interesting changes in brain activity, causing the visual cortex to receive more information from the region of the brain associated with mental imagery and personal memory. Under the influence of both music and LSD, the study participants reported seeing even more complex visions, such as memories played out as scenes.
"Scientists have waited 50 years for this moment -- the revealing of how LSD alters our brain biology," said senior researcher David Nutt , Edmon J Safra Chair in Neuropsychopharmacology.
"For the first time we can really see what's happening in the brain during the psychedelic state, and can better understand why LSD had such a profound impact on self-awareness in users and on music and art. This could have great implications for psychiatry, and helping patients overcome conditions such as depression."
